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KMID : 0360219700110040013
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Journal of the Korean Ophthalmological Society
1970 Volume.11 No. 4 p.13 ~ p.15
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Effect of Ouabain on Intraocular Pressure in Rabbits
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Abstract
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Effect of Ouabain administration on aqueous humor dynamics were studied in albino rabbits. Intravenous injection of 0. 1 mg/kg of ouabain in 10 rabbits produced significant reduction of intraocular pressure. The highest lowering of intraocular pressure occurred 70 minutes after the injection, its magnitude being 35.54% of the original pressure. The intraocular pressure returned -to its original pressure 117. 0 minutes after the injection. Perilimbal suction cup studies revealed 26.92% reduction in aqueous flow.
Intravitreal injection of 0. lmg of ouabain dissolved in 0.02m1 performed in 5 rabbits´ eyes produced marked lowering of intraocular pressure. The maximum tension-lowering effect (60.15%) was observed 4. 6 days after the administration, and the tension recovered 15. 8 days after the injection. Perilimbal suction cup studies showed 29.48% reduction in aqueous flow. It is concluded that Na-K ATPase play an important role in the aqueous formation and that ouabain lowers the intraocular pressure by suppressing this enzyme. Intravitreal administration has more powerful tension-lowering effect than intravenous injection.
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